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KMID : 1123920160300020095
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Korean Journal of Oriental Physiology and Pathology
2016 Volume.30 No. 2 p.95 ~ p.100
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Effects of the Water Extracts of Mantidis Ootheca, Rosa Laevigata, and Imperata Cylindrica on Blood Pressure in Renovascular Hypertension Induced by 2K1C
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Kim Hye-Yoom
Ahn You-Mee
Kho Min-Chul
Park Ji-Hun
Lee Jae-Yun
Lee Soo-Ho
Park Sueng-Hyuk
Kim Byung-Suk
Kang Dae-Gill
Lee Yun-Jung
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Abstract
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The aim of the present study is to investigate the hypotensive effect of Mantidis ootheca (WMO), Rosa laevigata (WIC), and Imperata cylindrica (WRL) in renovascular hypertension rats. Experimental hypertension model is 2-kidney and 1-clip (2K1C) induced rats. 2K1C rats were treated with WMO, WIC, and WRL at dose of 100 mg/kg/day orally for 3 weeks, respectively. Treatment groups with WMO, WIC, and WRL significantly lowered blood pressure. Interestingly, WMO, WIC, and WRL ameliorated endothelium-dependent and independent vascular relaxation in the phenylephrine-precontracted thoracic aorta in hypertension models. In addition, 2K1C-induced hypertension model increased plasma renin activity, however, WMO, WIC, and WRL attenuated those activities. These results suggest that WMO, WIC, and WRL ameliorates vascular dysfunction in 2K1C-induced hypertension models via the regulation of nitric oxide and renin-angiotensin-aldosterone system.
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KEYWORD
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Mantidis ootheca, Rosa laevigata, Imperata cylindrica, 2-kidney and 1-clip, Nitric oxide, Renovascular hypertension, Renin-angiotensin-aldosterone syste
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